Grating-coupled interferometry – the weak fragment hit biosensor assay

Grating-coupled interferometry (GCI) is ideally suited for fragment-based drug discovery due to inherent sensitivity of the detection principle, and the ability to capture fast transitions. It uses the refractive index changes that occur with protein binding and are measured as time-dependent phase-shift signals. Explore how the Creoptix^® WAVEsystem combines GCI with innovative no-clog microfluidics, permitting the study of biomolecular interactions using crude, unpurified samples, or in complex matrices, such as serum, plasma, or cell supernatant. The WAVEsystem uses a robust sensor and microfluidics cartridge, the WAVEchip^®, with four parallel flow channels, available in different surface matrix chemistries suitable for diverse applications, such as protein, antibody, VLPs, lipids, and others.