Inaugural open access issue of SLAS Discovery paves way for 2022

Historically, SLAS Discovery focused primarily on automation, screening, and its application to drug discovery. Responding to the evolution of science, the scope of publication broadened to include scientific and technical advances in target identification/validation (including chemical probes, RNA silencing, gene editing technologies), biomarker discovery, assay development, virtual, medium- or high-throughput screening (biochemical and biological, biophysical, phenotypic, toxicological, ADME), lead generation/optimization, chemical biology, and informatics (data analysis, image analysis, statistics, bio-, and chemo-informatics).

SLAS is committed to continuing to deliver high-quality research into 2022 and beyond. Special Issues and Collections focused on cutting-edge topics in rapidly moving fields will continue to be published into the new year. Upcoming issues include “3D Cell Culture Approaches of Microphysiologically Relevant Models,” as well as an “Early Career Scientist Showcase.”

SLAS Discovery, “will continue to respond as necessary to the changing environment for the benefit of our readers and the scientific community,” according to Ally Jump and Robert M. Campbell, Ph.D., Editor-in-Chief, in the January issue editorial. “In 2022, we are opening our content up to the world, free of access or subscription fees, knowing that it will propel our science forward and enable us to progress even more quickly than before.”

In addition to the editorial, this issue of SLAS Discovery also includes seven articles of original research and one review:

• Fragment-based screening: A new paradigm for ligand and target discovery
• Identification of potent small molecule inhibitors of SARS-CoV-2 entry
• Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies
• Deep learning image analysis of high-throughput toxicology assay images
• Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines
• Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay
• High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes
• High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes

Become a SelectScience member for free today to stay up to date with the latest science news >>