New Poster Demonstrates Pfizer’s Use of High Throughput Data Processing Capabilities in Thermo’s Galileo LIMS™ for Automated ADMET Profiling

Thermo Electron Corporation, the world leader in Laboratory Information Management Systems (LIMS), will co-present with scientists from Pfizer Global Research & Development a new technical poster demonstrating the use of its Commercial-Off-The-Shelf (COTS) Galileo LIMS™ for the automation of high throughput data processing for ADMET profiling.

Galileo LIMS™ is an integrated informatics solution designed specifically for in vitro ADMET profiling. The poster, to be presented at AAPS, October 29 – November 3, 2006, discusses reasons Pfizer selected a dedicated LIMS to address in vitro ADMET data and to broadly disseminate that information for maximum use throughout its organization.

Entitled, “Use of a Data Management System to Handle Data Processing, Storage and Uploading for In Vitro ADME Data in Drug Discovery,” the poster was authored by researchers at Pfizer Global Research & Development, departments of Pharmacokinetics Dynamics & Metabolism and Research Informatics, as well as product developers at Thermo.

The presentation focuses on advantages the LIMS provides in enhancing the value of acquired data by ensuring consistency in the ADME calculations and facile uploading to corporate databases for broad dissemination and impact.

“Historically, lack of a single, consistent approach for calculating, collecting and reporting in vitro ADME data resulted in multiple systems to upload data into global data warehouses from multiple in-house developed systems,” said Cornelis Hop, senior director at Pfizer. “Thus, a comprehensive data management system is needed to enhance data handling, processing and uploading to corporate databases.”

The poster discusses the importance of ADMET profiling for efficient drug candidate selection and optimization. It further highlights the challenges facing the high throughput drug discovery laboratories when managing data from a large numbers of compounds and a wide variety of in vitro ADMET screening assays and methods.

The poster also provides an overview of the data processing capabilities of Thermo’s Galileo LIMS. Galileo LIMS is capable of rapidly designing, calculating and reporting in vitro absorption, metabolism, inhibition and kinetic ADME data in an automated manner. The raw LC-MS data can be imported via rapid study entry using a simple, single dialog form, thus creating new studies and projects on-the-fly and populating the templates' design with study data. ADME parameters are flagged with green, yellow or red flags indicating acceptable, questionable or rejected results for each drug candidate. Galileo LIMS also features an “IC50 shift”, a new experiment type to elucidate enzyme inactivation, while it also offers support for PAMPA permeability studies that are important in early screening of compounds.

The new technical presentation can be found here.