Research Collaboration Looks to Develop CAR-T Cell Immunotherapy with Affimer Technology

Avacta Group plc, the developer of Affimer^® biotherapeutics and research reagents, has announced a research collaboration with Memorial Sloan Kettering Cancer Center (MSK), to evaluate the use of Avacta’s Affimer technology in novel CAR-T cell-based immunotherapy.

CAR-T immunotherapy is a form of cancer treatment, in which the patient’s own immune system T cells are modified to give them greater potency with which to attack cancer cells. Treatments using these engineered immune cells have generated promising responses in patients with advanced cancers. CAR-T immunotherapy has become an intense area of research, clinical development and investment.

The simple structure and biophysical properties of Affimer molecules potentially provides significant advantages over antibody fragment technology currently used in CAR-T cell modification. The collaboration announced today is intended to demonstrate a new class of CAR-T cell therapy that incorporates Affimer molecules.

The collaboration will be led by Renier J. Brentjens, MD, PhD, Director of Cellular Oncology at Memorial Sloan Kettering Cancer Center in New York.

As part of the collaboration Avacta will develop Affimer molecules that bind different regions of CD19, a surface protein specific to B-cells involved in lymphomas. Dr Brentjens’ team will construct CAR-T cells incorporating these Affimer molecules, and test their anti-tumour function in vitro and in in vivo animal efficacy models.

Dr Alastair Smith, Chief Executive Officer, Avacta, commented: “CAR-T cell therapy is an emerging and very exciting area of immuno-oncology which holds enormous clinical potential. We are delighted to be working with a world-leading team in the field to demonstrate the benefits that Affimer technology could bring to CAR-T therapy. The generation of positive data in these validated models of disease has the potential to open up highly valuable licensing and partnering opportunities for Avacta in this therapy area, which has attracted so much attention in the past couple of years.”