Thermo Fisher Scientific Introduces New Tools to Study Active Serine Hydrolases

Thermo Fisher Scientific, the world leader in serving science, today announced the introduction of novel reagents for the study of active serine hydrolases. The Thermo Scientific ActivX Serine Hydrolase Probes contain a fluorphosphonate (FP) element that specifically binds to the active site of serine hydrolases. The probes enable enrichment of serine hydrolase enzymes and determination of enzymatic activity using fluorescent SDS-PAGE, Western blot or mass spectrometry (MS) workflows.

Three ActivX® Serine Hydrolase Probes are available. The ActivX TAMRA-FP Probes can be used to label and detect serine hydrolase activity in samples using fluorescent gel imaging, capillary electrophoresis or MS. The ActivX Azido-FP Probes can be used in combination with phosphine- or alkyne-derivatized tags for detection or enrichment. Lastly, the ActivX Desthiobiotin-FP Probes can be used for detection and enrichment of active-site-labeled proteins by Western blot and MS.

The ActivX Serine Hydrolase Probes provide sufficient reagent for 100 labeling reactions or 10 pull-down reactions. The probes store easily at -80°C for up to one year. For more information on the probes, please visit the company article page.