Ultra Fast LC without the hassle of Ultra High Pressure

Chromolith^® FastGradient RP-18e 50-2mm is the new monolithic HPLC column from Merck KGaA, Darmstadt, Germany which will be the key exhibit at the EMD Chemicals Booth at HPLC 2008 in Baltimore.

The image (right) shows a typical application – ultra-fast separation of 10 antihistamine standards in less than 2½ minutes. The most amazing thing about this separation is however the pressure. The chromatogram was run at pressures below 120 bar (1700 psi).

Thanks to this new technology, ultra-fast HPLC no longer requires ultra-high pressure. The column opens the way to ultra-fast separations with standard HPLC systems at standard pressures!

Key application areas will include pharmacokinetics and metabolism studies (DMPK) and other areas of high-throughput analysis and LC/MS.

This column is a clear alternative to sub-2µm particle columns, which often require specialized UHPLC or UPLC™ type instruments.