Ultra-Fast Preparative and Purification Liquid Chromatograph

Shimadzu, one of the world leaders in analytical instrumentation, has released the "Prominence UFPLC" Ultra-Fast Preparative and Purification Liquid Chromatograph, which enables fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products.

Conventional workflows utilizing preparative liquid chromatography (Prep LC) yield fractions with significant water content which can take eight hours or more to evaporate and typically cannot be completely removed, resulting in a powder with poor weight purity.

The Prominence UFPLC offers a single automated workflow that utilizes on-line fraction trapping as an alternative to traditional fraction collection, allowing elution of collected compounds in highly volatile organic solvents that can easily be evaporated, resulting in ultrahigh weight purity compounds in about 90 minutes. The Prominence UFPLC greatly improves the efficiency of preparative fraction collection and purification workflows in pharmaceutical, food, chemical and other industries as well as research organizations.

Prep LC is a widely used technique in many research, development and manufacturing applications, including synthesis of new drug compounds, discovery of active components in natural products and as a mechanism to collect large amounts of unknown compounds in foods and drugs for subsequent structural analysis. In 2013, Shimadzu released the "Crude2Pure" Automated Purification/Powderization System, which removed mobile phase contaminants from PrepLC fractions and returned a highly pure and very dry powder with an option to recover that powder as a free base. Prominence UFPLC inherits the breakthrough fraction trapping and purification technology at the core of Crude2Pure and expands on it to provide a comprehensive on-line automated purification process.

Key Features

• Recover ultrapure compounds from a complex sample in 1.5 hours
• High purity compounds, optionally recovered as a free base
• Optimized instrument footprint providing cost-effective solution
  

With the introduction of Prominence UFPLC, Shimadzu expands its extensive chromatography portfolio to include a comprehensive automated solution for preparative separations, fraction purification and compound powderization, contributing greatly to improved efficiency in any application requiring preparative purification.