Using humanized in vivo models for pre-clinical antibody development: A case study

The pre-clinical development of engineered antibodies presents unique challenges linked to their human-specific molecular functions.

Researchers at The Jackson Laboratory (JAX) have developed several humanized mouse models to test in vivo the different features of engineered antibodies. In this poster, the Jackson Laboratory (JAX) present Rituximab as an example of the use of JAX’s in vivo tools for the preclinical development of engineered antibodies.