The Swiss Army Knife of Ligand Binding Assays

The Swiss Army knife of ligand binding assays

The Swiss Army knife is the perfect combination of form and function, found in countless pockets, purses, and packs simply because of its innumerous uses. Scientists rely on analytical tools every day to make pivotal decisions throughout the drug discovery, development, and manufacturing process. While many biophysical analytical tools are suited for detecting structural changes, few can assess structure-dependent function in the same system.​

This interactive resource outlines the power of label-free protein-protein and protein-small molecule interaction characterization. We invite you to browse our extensive resource library that has been organized by application area as well as workflow stage, making it easy to find the right information and advice for your area of expertise.

Biomolecular interaction analysis such as binding kinetics requires highly technical skills. This handbook like compendium provides not only general answers on technology, assay design or data analysis questions. It also contains tips and tricks of successfully running label-free assays, whether you are a beginner or long-year experienced scientist working on a SPR or BLI system.

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The Swiss Army knife is the perfect combination of form and function, found in countless pockets, purses and bag packs simply because of its countless uses. Scientists rely on analytical tools every day to make pivotal decisions throughout the drug development and manufacturing process. While many biophysical analytical tools are suited for detecting structural changes, few can assess structure-dependent function in the same system.​

This interactive resource outlines the power of label-free biologics characterization by enabling you to browse our extensive resources to easily find the right information and advice for your application.

Browse our resources by application:

Or browse by your workflow step:

Browse resources by application

Binding kinetics

Steady state affinity

Sample quantification

Epitope mapping

Browse resources by workflow step

Research

Screening

Lead characterization

Lead optimization

Preclinical & clinical

Manufacture & QC

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Protein-protein interactions specificity

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Binding kinetics

Antibody off-rate ranking

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Affinity ranking

Lead optimization

Small molecule characterization

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Antibody quantification

Clone selection by productivity screening

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Hybridoma screening

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Residual contaminant detection

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Glycan profiling

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AAV titer

Epitope binning

Potency

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Critical quality attributes

Immunogenicity

Rapid and real-time results for the study of viral biology and development of antiviral therapies

In this exclusive interview, Dr. Rebecca DuBois, Associate Professor in the Department of Biomolecular Engineering at the University of California, Santa Cruz, outlines the advantages of using Sartorius' Octet® platform in her research to understand the molecular mechanisms of human viral infection and to develop new vaccines and antiviral therapies.

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A robust and flexible analytical characterization portfolio for biotherapeutics

The "Swiss Army knife" solution

The Octet® R8 utilizes bio-layer interferometry (BLI) technology to enable the direct detection of specific proteins and other biomolecules and an advanced fluidics-free approach to protein characterization.

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