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1-Oleoyl Lysophosphatidic Acid
Lysophosphatidic acid (LPA)1 and LPA2 agonist
1-Oleoyl Lysophosphatidic Acid
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1-Oleoyl Lysophosphatidic Acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. LPA mediates a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility (Moolenaar).
DIFFERENTIATION
- Stimulates neuronal differentiation in cultured mouse or rat neural progenitor cells (Cui and Qiao; Fukushima et al.; Spohr et al.).
- Inhibits human embryonic stem (ES) cell-derived neural stem cells (NSCs) from forming neurospheres and differentiating into neurons in vitro (Dottori et al.).
- Stimulates differentiation of human adipose tissue-derived mesenchymal stem cells to myofibroblast-like cells in vitro (Jeon et al.).
