3dGRO™ Human Lung Organoid Culture System
The 3dGRO™ Human Lung Organoid Culture System is a multi-stage culture system for efficient differentiation of human induced pluripotent stem (iPS) cells to mature lung organoids.
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Lung organoids are 3D cell culture models that possess a complex tissue architecture that more closely resembles in vivo tissues and can be used for studying human lung development and respiratory diseases including viral infections (SARS-CoV, H1N1, MERS), cystic fibrosis, asthma, COPD, and the effects of air pollution and smoking.
The 3dGRO™ Human Lung Organoid Culture System is a serum-free, multi-stage culture system for efficient differentiation of human induced pluripotent stem (iPS) cells to mature lung organoids. Using the 3dGRO™ Human Lung Organoid Culture System, large numbers of mature lung organoids can be generated that express markers found in the mature lung and airways including SFTPB and SFTPC (surfactant protein B and surfactant protein C), MUC5AC, EpCAM, Sox9 and Nkx2.1, acetyl-α-tubulin, and vimentin. Additionally, lung organoids express angiotensin-converting enzyme 2 (ACE2), the receptor for the novel SARS-CoV-2 virus that causes COVID-19, along with TMPRSS2, the serine protease that enhances SARS-CoV-2 viral entry.
