Amyloid B Auto-Ab (Serum) ELISA
High Quality Assays with Reproducible and Reliable Results
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The DRG Amyloid Beta Auto-Ab ELISA is an enzyme immunoassay for the quantitative in vitro measurement of autoantibodies against Amyloid Beta (ABeta) in human serum.For research use only.The Amyloid Beta (ABeta) protein consists of 40-42 (43) amino acids and is cleaved from Amyloid Precursor Protein (APP) by Beta-secretase and subsequent γ-secretase. The increased release of ABeta42/ABeta43 leads to the abnormal deposition of human ABeta and the associated neurotoxicity in the brains of affected individuals.1, 2The DRG Amyloid Beta Auto-Ab ELISA Kit is a solid phase enzyme-linked immunosorbent assay (ELISA) based on the sandwich principle. The microtiter wells are coated with (1-42) Beta-Amyloid. An aliquot of patient sample containing ABeta-autoantibodies is incubated in the coated well with assay buffer. After washing a second incubation with enzyme conjugate, which is goat anti-human IgG conjugated to horseradish peroxidase, follows. After incubation the unbound conjugate is washed off. The amount of bound peroxidase is proportional to the concentration of autoantibodies against ABeta in the sample. Having added the substrate solution, the intensity of colour developed is proportional to the concentration of autoantibodies against ABeta in the patient sample.
