antibody, mouse clone 10-11
Product Type: antibody. Immunogen: native, from plasma. Host: mouse. Type: monoclonal. Clone: 10-11. Subclass: IgG1-k. Format: affinity purified Ig. Preparation: Protein A chromatography. State: liquid. Buffer: borate buffered saline, pH 8.4, 0.1% sodium azide. Storage: aliquot and store at -20°C.Cross reactivityDoes not react with C4c. Does not cross react with cow, cat, dog, guinea pig, mouse, rabbit, sheep or rat.Specificit…
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Product Type: antibody. Immunogen: native, from plasma. Host: mouse. Type: monoclonal. Clone: 10-11. Subclass: IgG1-k. Format: affinity purified Ig. Preparation: Protein A chromatography. State: liquid. Buffer: borate buffered saline, pH 8.4, 0.1% sodium azide. Storage: aliquot and store at -20°C.
Cross reactivity
Does not react with C4c. Does not cross react with cow, cat, dog, guinea pig, mouse, rabbit, sheep or rat.
Specificity
Reacts with an antigen which is expressed in the C4d domain of native C4 and C4d. Although not tested for the C4d domain of C4b, it very likely binds this as well.
Immunohistochemistry
It has been reported that this antibody works very well on acetone-fixed, frozen renal biopsies at a dilution of 1/500-1/600. Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).
Antigen preservation
Use on paraffin embedded sections has given variable results. It has been observed that pre-treatment with 88% formic acid for 20 minutes at room temperature is beneficial.
Applications
This antibody is also suitable for use in FACS.
