ApoE Knockout Rabbit
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease. ApoE Knockout Rabbit Characteristics: 8 bp deletion within Exon 3 Homozygous knockouts exhibit complete loss of ApoE protein via Western bl…
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Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease.
ApoE Knockout Rabbit Characteristics:
- 8 bp deletion within Exon 3
- Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
- At four months of age, ApoE knockout rabbits demonstrate serum cholesterol levels 2-5x greater than wildtype
- At four and five months of age, ApoE knockout rabbits demonstrate triglyceride levels up to 2x greater than wildtype
- Background Strain: New Zealand White
Research Applications:
- Atherogenesis
- Atherosclerosis
- Hypertension
- Insulin resistance
- Lipoprotein/Cholesterol transportation
- Metabolism (Triglyceride/Cholesterol)
- Obesity
- Type II diabetes
