ApoE Knockout Rat
In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies. Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.ApoE Knockout Rat Characteristics: 16 bp deletion wit…
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Review Date: 26 Jun 2021 | SAGE Labs
In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies.
Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.
ApoE Knockout Rat Characteristics:
- 16 bp deletion within Exon 3 on chromosome 1
- Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
- Administration of high fat diets to ApoE KO rats has resulted in significantly reduced lifespan.
- SAGE Labs does not recommend administering high fat diets to ApoE KO rats.
- At an early age (5- and 10-week-old), ApoE knockouts demonstrate significantly higher serum cholesterol
- Background Strain: Sprague-Dawley
Research Applications:
- Atherogenesis
- Atherosclerosis
- Hypertension
- Insulin resistance
- Lipoprotein/Cholesterol transportation
- Metabolism (Triglyceride/Cholesterol)
- Obesity
- Type II diabetes
