Products & ReviewDrug discovery > Drug Manufacturing
Avanti® Polar Lipids 18:1 PI(4,5)P2
Merck KGaA, Darmstadt, Germany850155PAvailable: ,Western Europe,Asia,Eastern Europe,South Central America,Caribbean,Australia Oceania,Middle East,Africa,Other
1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate) (ammonium salt), powder
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Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Packaging
- 2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-100ug)
- 2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-500ug)
