Products & ReviewDrug discovery > Drug Manufacturing
Avanti® Polar Lipids Brain PI(4,5)P2
Merck KGaA, Darmstadt, Germany840046PAvailable: ,Western Europe,Asia,Eastern Europe,South Central America,Caribbean,Australia Oceania,Middle East,Africa,Other
L-a-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), powder
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Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Packaging
- 5 mL Clear Glass Sealed Ampule (840046P-10mg)
- 5 mL Clear Glass Sealed Ampule (840046P-1mg)
- 5 mL Clear Glass Sealed Ampule (840046P-25mg)
- 5 mL Clear Glass Sealed Ampule (840046P-5mg)
