BIO-Acetoxime

BIO-Acetoxime is an analog of the GSK3 inhibitor BIO (Catalog #72032). It potently inhibits GSK3α and GSK3β (IC₅₀ = 10 nM), and less potently inhibits cyclin-dependent kinases Cdk5/p25, Cdk2/A, and Cdk1/B (IC₅₀ = 2.4, 4.3, and 63 µM, respectively; Meijer et al.; Polychronopoulos et al.). By inhibiting GSK3β, BIO-Acetoxime blocks β-catenin phosphorylation and degradation, thereby allowing it to activate transcription of WNT pathway-controlled genes (Meijer et al.).

IMMUNOLOGY

• Inhibits CD8+ effector T cell differentiation (Zhou et al.).
• Suppresses viral gene expression and protects oral epithelial cells from herpes simplex virus-1 infection (Hsu & Hung).