Products & ReviewLife Sciences
BMS 493
Retinoid pathway activator; Activates pan-retinoic acid receptor
BMS 493
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BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).
DIFFERENTIATION
- Affects development of bronchial tubule formation in mice (Chazaud et al.).
- Inhibits activation of immature dendritic cells (Geissmann et al.).
CANCER RESEARCH
- Inhibits differentiation of leukemic blasts (Kamashev et al.).
