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Cardiogenol C

Inducer of cardiac differentiation

STEMCELL Technologies Inc.

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Cardiogenol C is a diaminopyrimidine that induces cardiomyogenesis in mouse embryonic stem cells. Its use results in expression of GATA-4, MEF2, and Nkx2.5.

REPROGRAMMING

  • Induces trans-differentiation of mouse CD34+K15+ hair bulge progenitor cells into cardiomyocyte-like cells (Yau et al.).
  • Induces cardiomyogenic function in the lineage-committed progenitor cells, C2C12 skeletal myoblasts and mouse A5 cardiovascular progenitor cells (Mike et al.).

DIFFERENTIATION

  • Induces the differentiation of myosin heavy chain (MHC)-positive cardiomyocytes from mouse embryonic stem cells (Wu et al.).

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