Products & ReviewLife Sciences
CAY10603
Epigenetic modifier; Inhibits histone deacetylase (HDAC) 6
CAY10603
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CAY10603 is a selective and potent inhibitor of histone deacetylase 6 (HDAC6; IC₅₀ = 0.002 nM; Kozikowski et al.). HDAC6 deacetylates lysine residues on the N-terminal part of histones. HDAC6 is also known to regulate heat shock protein 90 (hsp90) via hyperacetylation (Rao et al.).
CANCER RESEARCH
- Inhibits growth of several pancreatic cancer cell lines (IC₅₀ = 0.1 - 1 μM) and SCCOHT, an ovarian cancer cell line (Kozikowski et al.; Wang et al.).
