Products & ReviewLife Sciences

CGP77675

Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK

STEMCELL Technologies Inc.

The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our  Product Directory.

Ease of Use
After Sales Service
Value for Money
Write your own review

CGP77675 is a potent inhibitor of Src family kinases. It has been reported to inhibit phosphorylation of peptide substrates and autophosphorylation of purified Src (IC₅₀ = 5 - 20 nM and 40 nM, respectively), Src, and Src kinase family members such as LCK (IC₅₀ = 0.02 mM and 0.29 mM, respectively). It has also been shown to inhibit epidermal growth factor receptor (EGFR), Cdc2, v-Abl, and focal adhesion kinase (FAK) (IC₅₀ = 0.15 mM, > 10 mM, 0.31 mM, and 0.2 mM, respectively; Missbach et al.).

MAINTENANCE AND SELF-RENEWAL

  • In combination with the GSK3 inhibitor CHIR99021 (Catalog #72052), CGP77675 is used to maintain mouse embryonic stem (ES) cells (Shimizu et al.).
  • Preserves the epigenetic and genomic integrity as well as the developmental potential of ES cells (Choi et al.).

Product Overview

Links