CL100-ProliFiler
ProQinase's CL100-ProliFiler is a standard service package comprising IC50 determination of your test compounds on the proliferation response of a defined panel of 100 tumor cell lines.
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More than 60 % of the lately emerged first-in-class drugs are derived from phenotypic cellular screenings. For analysis of the impact of anti-cancer drugs, the most common cellular phenotypic assay is the 2D proliferation assay in which tumor cells grow in suspension or as monolayers. This assay allows testing of large numbers of compounds in a rapid cost-efficient fashion.
ProQinase’s proliferation assays are based on the quantification of the live cell population after 72 hours of compound incubation. Our standard proliferation assay service, the CL100-ProliFiler, is designed for parallel testing of compounds on a fixed panel of 100 oncological relevant tumor cell lines covering a broad range of entities. Due to its setup in 384 well plates the CL100-ProliFiler is well-suited for testing of large compound numbers. Application of compounds by nanodrop dispension requires only small compound amounts and allows elaborate combination studies. Gene expression data on all cell lines, inhibition profiles of selected standard-of-care compounds or analyses of individual cell lines are available on request. ProQinase´s broad service portfolio allows for a multitude of potential follow-up studies on the very same cell lines.
Key features:
- 2D proliferation/viability assay
- testing on a panel of 100 tumor cell lines
- IC50 determination
- 72 hours incubation time
- available in 384 well format
- rapid turnaround time
Relevant applications:
- phenotypic cellular screening of anti-cancer drugs
- testing of large compound numbers
- suitable for combination studies
