Products & ReviewLife Sciences
Compound E
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
Compound E
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Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.).
DIFFERENTIATION
- Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
- Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
