Products & ReviewLife Sciences
Cyclic Pifithrin-Alpha
p53 Inhibitor
Cyclic Pifithrin-Alpha (Hydrobromide)
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Cyclic Pifthrin-Alpha is a cell-permeable and reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription. It is a more stable and less cytotoxic analog of the non-cyclic form of pifithrin-alpha. Cyclic Pifithrin-Alpha has also been reported to activate the aryl hydrocarbon receptor. (Fernandez-Cruz et al., Gary & Jensen, Komarov et al.)
REPROGRAMMING
- Increases efficiency of reprogramming mouse embryonic fibroblasts to induced pluripotent stem cells (Liao et al.).
MAINTENANCE
- Reduces UV-induced apoptosis of mouse embryonic stem cells (Qin et al.).
- Increases the numbers of mouse hematopoietic stem and progenitor cells in vivo and in vitro, also decreases the radiation-induced death of these cells (Leonova et al.).
