Products & ReviewLife Sciences
Cyclopamine
Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)
Cyclopamine
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Cyclopamine is a steroid alkaloid that inhibits the Hedgehog pathway at the point of the pathway activator Smoothened. Cyclopamine binds to the heptahelical bundle of Smoothened, a G protein-coupled receptor, and prevents it from signaling further downstream (Chen et al.).
MAINTENANCE
- Reduces proliferation of rat neural progenitor cells and mouse neurospheres (Lai et al.; Palma and Ruiz i Altaba).
- Reduces proliferation of mouse mammospheres (Liu et al.).
DIFFERENTIATION
- Promotes differentiation of pancreatic cells from human embryonic stem cells (D'Amour et al.).
CANCER RESEARCH
- li>Inhibits the growth of human and mouse medulloblastoma cells, and human glioblastoma cells (Bar et al., Berman et al.).
