Products & ReviewLife Sciences
D4476
Activin/NODAL/TGF-ß pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK
D4476
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D4476 is a selective, potent, and cell-permeant inhibitor of casein kinase (CK) 1 (Rena et al.). It inhibits CK1 and CK1δ from S. pombe (IC50 = 200 nM and 300 nM, respectively; Bain et al.; Rena et al.). It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with IC50 = 500 nM (Rena et al.).
REPROGRAMMING
- Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).
- Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).
CANCER RESEARCH
- Induces apoptosis of multiple myeloma cell lines (Hu et al.).
- Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Jí¤rí¥s et al.).
