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Dorsomorphin
BMP and AMPK pathway inhibitor; Inhibits ALK2, ALK3, ALK6, and AMPK
Dorsomorphin
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Dorsomorphin inhibits the BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. It is also a potent inhibitor of AMPK (Ki = 109 nM) but does not significantly inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA or JAK3. (Bain et al., Yu et al.)
DIFFERENTIATION
- Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Morizane et al., Zhou et al.).
- Promotes differentiation of cardiomyocytes from mouse and human pluripotent stem cells (Hao et al., Kattman et al.).
- Promotes differentiation of adipocytes and suppresses osteogenic differentiation of osteoblasts from human mesenchymal cells (Kim et al.).
