EPIgeneous™ Binding Domain Assays
EPIgeneous™ Binding Domain Assay Kits for studying epigenetic readers. This biochemical assay platform enables a no-wash, sensitive, reliable detection of protein/protein interaction between epigenetic binding domains and histone sequences modified by epigenetic enzymes. Three assay kits (A, B and C) have already been validated and fully optimized on a selection of 28 key binding domains. For non-validated reader domains, a f…
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EPIgeneous™ Binding Domain Assay Kits for studying epigenetic readers.
This biochemical assay platform enables a no-wash, sensitive, reliable detection of protein/protein interaction between epigenetic binding domains and histone sequences modified by epigenetic enzymes. Three assay kits (A, B and C) have already been validated and fully optimized on a selection of 28 key binding domains. For non-validated reader domains, a fourth kit (Discovery) enables you to profile which of the A, B or C kits is the best assay solution. All kits are based on a GST-tagged Binding Domain /biotin-coupled Histone peptide format, and can be run using the same mix-and-read single plate protocol. EPIgeneous™ Binding domain assay kits are ideal assay tools for both primary and secondary screening as well as for further inhibitor studies.
Features:
- Fully optimized on 28 key reader proteins
- High sensitivity and robustness for inhibitor screening
- Good DMSO tolerance
- Low consumption of protein and peptide
Applications:
- Bromodomain, Chromodomain, Tudordomain & MBT domain assays
- High Throughput Screening
- Inhibitor profiling
