Enabling Epigenetics Studies from HTS to SAR: a Novel HTRF® Platform to Identify and Characterize Reader Domain Inhibitors

This poster describes a novel assay platform based on HTRF technology which enables the discovery and the characterization of novel reader domain inhibitors. More than 20 different assays have been built up to monitor the interaction of Bromodomain, Tudor domains, MBT domains and Chromodomains with histone peptides.