Products & ReviewLife Sciences
eSpCAS9 Protein
Enhanced specificity Cas9-NLS from Streptococcus pyogenes, expressed in Escherichia coli
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Newly engineered eSpCas9 enables the efficient targeted gene editing of established CRISPR systems with the benefit of reduced off-target effects. Point mutations in the chromosome-binding motif of SpCas9, as described by Slaymaker, et al., provide higher on-target fidelity without loss of cleavage efficiency.[1]
[1] Rationally engineered Cas9 nucleases with improved specificity. Slaymaker, I.M., et al. Science 351, 84-8, (2015)
