FlowCam 8000
Through its exceptional image quality and the widest size range available, FlowCam® 8000 represents state-of-the-art particle imaging technology. Analyze thousands of particles in less than a minute and comprehensively characterize the size, count, morphology, and identity of subvisible and visible particulates in their native solvent.
C. elegans imaged on FlowCam 8000
Eyeshadow particles imaged on FlowCam 8000
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Makes my job 10x easier and enjoyable
Analyze Phytoplankton
I absolutely love working with this instrument, it is a dream. the capabilities are endless, I use it to process daily water samples and it has cut the analysing time in 1/2 if not by more, plus the fact you can store all the old data runs and look back on them whenever you please. It is an expensive instrument but in my eyes it is well worth the money.
Review Date: 13 Jan 2023 | Yokogawa Fluid Imaging Technologies, Inc
Great results, must have equipment in aquatic ecology lab
Aquatic ecology
The FlowCam is very effective for quick and reliable estimate of number of phytoplankton particles both in natural and laboratory samples. Great device to study zooplankton grazing as it is possible to estimate the amount of particles consumed and size range (selective feeding). It is preferably to use FlowCam with laser to measure phytoplankton as fluorescence helps to distinguish between algae and debris particles. I am using one of first FlowCams (2007 year of production). It is still reliable. Recently I had a n experience to use FlowCam8000 (2020 year of production). Great progress in usability. Now it is even more user friendly and efficient (new camera, new flow cells).
Review Date: 16 Feb 2022 | Yokogawa Fluid Imaging Technologies, Inc
Couldn't do my job without this instrument!
Analyze Phytoplankton
Absolutely love the FlowCam for phytoplankton monitoring - much faster than using a traditional microscope for counting, etc. Also means that every daily flow run can be saved which means you can go back to old runs from past years/months etc. Very easy to use the machine - would recommend using the FlowCam university which helps you understand how to use the instrument/tips for analysis.
Review Date: 15 Feb 2022 | Yokogawa Fluid Imaging Technologies, Inc
Very functional for my work.
Harmful Algae Bloom Monitoring
The flow cytometer with image acquisition - FlowCam - is very useful equipment for monitoring harmful algae, especially here in southern Chile, which we use to serve the salmon industry. It works very well, it works easily and simply and the maintenance cost is not high. Need a technical professional to use the equipment. The software can still advance in many areas of improvement, such as the interface and the classification system, using machine learning. Also as an accumulative and cooperative effect among users.
Review Date: 7 Feb 2022 | Yokogawa Fluid Imaging Technologies, Inc
Great for phytoplankton
Great machine for phytoplankton studies
This machine works well and is a lot faster than traditional microscopy. Although there is a lot to learn with this machine, Fluid Imaging has excellent customer service and is always quick to respond to my questions. The major drawback to this machine is that it is less precise than traditional microscopy so it will not always get you to species-level identification. I prefer to use the FlowCam 8000 to traditional microscopy when possible.
Review Date: 3 Feb 2022 | Yokogawa Fluid Imaging Technologies, Inc
Super useful instrument for my research.
Phytoplankton and zooplankton identification
The FlowCam is great - I love using it more than a traditional microscope. I will say that it is a little hard to understand some of the statistical applications and sometimes the photos don't come out clear but that just means you have to tweak it a little. Doing wild samples leads to more discrepancies but overall the FlowCam greatly enhances my ability to conduct research.
Review Date: 3 Feb 2022 | Yokogawa Fluid Imaging Technologies, Inc
Great purchase
Measuring protein solutions
We only have a problem with filtering particles, after setting filters with groups of sphere and proteins , the system does not recognize them and we have to classify by hand.
Review Date: 3 Feb 2022 | Yokogawa Fluid Imaging Technologies, Inc
Manufacturer's Response
Dear Ms. Petric, Thank you for your valued feedback. We’re sorry to learn that you are experiencing a limitation of our software capabilities. We are actively working on adding a feature that would allow you to perform filtering and subsequent classification automatically to address the issue you describe above. One of our representatives will work with you to ensure that the feature will work as intended. Sincerely, Yokogawa Fluid Imaging Technologies
Valuable tool for in-flow observation of ephemeral particulate or microbial phenomena.
Evaluation of cell-particle interactions
We used the FlowCam 8000 in recently published work on evaluating the bacterial capture capacity of a novel class of hydrophobic dispersive solvent, magnetic ionic liquids (MILs). The FlowCam 8000 was very useful in providing insights that were not available using traditional microbiological or microscopic techniques. Specifically, we were able to observe the impact of the ionic strength of the medium in which the MILs were dispersed. Parameters examined included droplet size and distribution as a function of ionic content. Of special note, the FlowCam 8000 also enabled us to observe extensive aggregation of MIL droplets in the presence of the bacterium Serratia marcescens, providing insights into the mechanism of action behind MIL-based capture and concentration of bacteria. The details of our study (Hice, S.A., Varona, M., Brost, A., Dai, F., Anderson, J.L. and B.F. Brehm-Stecher. 2020. Magnetic ionic liquids: interactions with bacterial cells, behavior in aqueous suspension and broader applications. Anal. Bioanal. Chem. 412(8): 1741-1755) can be found here: https://rdcu.be/b1u82
Review Date: 7 May 2020 | Yokogawa Fluid Imaging Technologies, Inc
Great results, superb accuracy and characterization!
Pharmaceutical QC & QA, new drug development, medical devices, food, feed and beverages...
Highly efficient and effective instrument in my lab. I am a manager for pharmaceutical and food testing labs for Central Testing Lab facility, Quality & Conformity Council of Abu Dhabi, UAE. We are government entity and enabler for regulators including Department of Health, Ministry of Water, Abu Dhabi Food and Safety Authority, AD Municipality & Environment Agency. We bought our first FlowCam 8000 two year back (2018). We found this machine highly efficient in many areas. Regulators removed dozens of substandard injectable products from the market because of FowCam 8000. Previously, It was impossible to pick defected units by following traditional pharmaceutical monographs for particulate matter. The beauty of FowCam is the evidence of live pictures of particles, which help us in characterizing and understanding the source of contamination. We can recognize, particles up to 1 micron easily which helps regulators to make decisions. Through FlowCam, we are able to guide manufacturers about sources of contamination. We can easily distinguish between fibers, polymers, silicone, dust particles, glass or even microbes. This instrument gave us confidence talking about this because of the real particle pictures we were able to generate. We are able to guide manufacturers about formulation issues. Especially regarding problems with particles due to API aggregates. Live assessment of particles and characterization help us with product stability too. Live, unexpected findings of microbial contamination in food and feed opens a new area of R&D. With the help of FlowCam we are making decisions with confidence. We can carry out particulate analysis in medical devices that was never possible before. Instrument operation is very straight forward. This instrument, does not need much services. Need little care regarding sample cleanliness. Users with little experience can manage the system by themselves. Here in the UAE, we are very lucky that local agent for FlowCam is very professional. Availability of NIST equivalent quality control solution with known particle size and numbers, give high confidence to reporting results to regulators and other clients. We normally start system injecting with blanks, to confirm no particulate contamination from the environment and then quality control (NIST) to confirm count and measure accuracy. Because of this instrument and generated data, we received high prestige and appreciation from higher government entities. Lots of success. More than 20 different parameters about each detected particle can be measured. As per our experience we recorded up to 200000 particles per ml. This shows the system is so fast and smart in capturing the data of each particle accurately. Findings of unexpected particles in food and feed samples, were reported to regulators because of FlowCam. Highly reproducible results for quality control. Very simple operation, need only a few hours to understand and train others. The beauty of system is that no one can manipulate/change the data. It's incompliance with GLP. Raw data is always available in its original form. No comparison with microscopic pharmacopoeia method. This instrument can be applied for pharmaceutical samples especially injections, very useful during formulation and stability testing. Very helpful in medical devices particulate assessment. Useful in marine water testing. Choice of different lenses and objects, based on particle size. Live microbiological identification is also possible through FlowCam. It is worth having a FlowCam 8000 in the lab. It’s a lifesaving instrument.
Review Date: 5 May 2020 | Yokogawa Fluid Imaging Technologies, Inc
Intuitive and easy to learn how to use.
Flow altology and imaging
The Flowcam is an intuitive and easy to learn flow based particle sizer and counter. The software lets us sort out the particles we are not interested in and it saves images and statistical information. We train end users on the operation of the device and it is something that graduates, undergrads and students have picked up with great ease.
Review Date: 12 Mar 2020 | Yokogawa Fluid Imaging Technologies, Inc
Through its exceptional image quality and the widest size range available, FlowCam 8000 represents state-of-the-art particle imaging technology. Analyze thousands of particles in less than a minute and comprehensively characterize the size, count, morphology, and identity of subvisible and visible particulates in their native solvent.
Flow Imaging Microscopy (FIM) combines the benefits of digital imaging, flow cytometry, and microscopy into a single solution. Beyond traditional particle sizing and counting, image-based analysis allows for comprehensive characterization of subvisible API aggregates and contaminants in biopharmaceuticals, mammalian cells, microplankton, emulsions, and advanced materials.
Benefits
- Obtain meaningful results in less than a minute, with as little as 100 μL of sample
- Sort, filter, and classify images based on 40+ morphological parameters
- Automatically identify particles with out-of-the-box machine learning tools for protein formulations
- Analyze samples in their native environment, including high-viscosity solvents and buffers
- Increase productivity with automated liquid handling for up to 384 samples
- Differentiate aquatic organisms with fluorescence detection in
FlowCam 8400 Specifications
- Particle sizing and imaging 2 µm to 1 mm with magnification options of 20X, 10X, 4X, and 2X
- Minimum sample volume of 100 µL
- Sample processing capability from 0.05 mL/minute up to 10 mL/minute, depending on flow cell configuration
- High-resolution camera available in color or monochrome
- Maximum particle concentration of 5 million particles/mL at 2.5 µm particle size
- Compatibility with ALH for FlowCam(TM) automated liquid handler
- Fluorescence excitation options (488 nm, 532 nm, 633 nm) with 2-channel fluorescence detection
