HLA-Typed Human Primary Cells
The HLA system of cell-surface proteins regulates the human immune system and is used in the development of pre-clinical cell therapy research and immuno-oncology drug discovery.
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The HLA system of cell-surface proteins regulates the human immune system and can be used as markers in research. A specific HLA type can be associated with an autoimmune disease (Mignot, Emmanuel, et al. 2001) or serve as a biomarker to show how cells respond to cancer treatments (Chowell et al. 2017). HLA types have also become important in understanding cardiovascular morbidity and mortality rates.
Unlike animal testing, HLA-typed cells provide an optimal control system to test cancer reactive T-cells in a culture that represents the human system. With the rapid development of cancer immunotherapies such as adoptive cell therapy, custom cells screened for their HLA types are increasingly important for developing and testing new drugs.
Key Advantages
- Minimize off-target interactions preclinically by testing translatability in a human cell setting.
- Better results than animal testing for the development and testing of new drugs.
- Buy with certainty your cells have the HLA type you need due to our HLA typing report – no need for further screening.
- Faster testing means shorter development time of new therapies for cancer patients.
- Test cross-reactivity of new therapies in multiple systems using our HLA-typed cells from lung, heart, kidney, or the cardiovascular system.
