Products & ReviewLife Sciences
HPI-1
Hedgehog pathway inhibitor
HPI-1
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HPI-1 is a Hedgehog (HH) pathway inhibitor that suppresses signaling through Sonic HH (IC₅₀ = 1.5 µM) without significantly affecting WNT signaling (IC₅₀ ≥ 30 µM) (Hyman et al.). HPI-1 suppresses HH activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of GLI protein or at the interaction of GLI with a co-factor (Hyman et al.).
MAINTENANCE AND SELF-RENEWAL
- Demonstrates the importance of Hedgehog pathway by inhibiting proliferation mediated by the oncogenic Smoothened (SMO) mutant, SMOM2 in cultured cerebellar granule neuron precursor cells (Hyman et al.).
CANCER RESEARCH
- Reduces growth of MDA-MB-231 breast cancer cells (Kwon et al.).
