Human Cav2.2/β3/α2δ1 Calcium Channel EZCells
The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely distributed in neurons, are therapeutic targets in neuropathic and inflammatory pain. Synonyms: N-type calcium channel Host cell: CHO-K1, division-arrested Gene name: CACNA1B/CACNB3/CACNA2D1 My…
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The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely distributed in neurons, are therapeutic targets in neuropathic and inflammatory pain.
Synonyms: N-type calcium channel
Host cell: CHO-K1, division-arrested
Gene name: CACNA1B/CACNB3/CACNA2D1
Mycoplasma status: Negative (MycoAlert Kit)
Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells
total)
Growth media: Ham’s F12; 10% FBS
Growth characteristics: cells remain viable 1–2 days post-thaw
Storage recommendation: frozen under liquid nitrogen
Functional expression: median Ca2+ current amplitude = 0.27 nA
Recommended assay: manual or automated patch clamp
