Products & ReviewLife Sciences
Human CRISPRi Kinase Phosphatase Drug Targets Kit
Human CRISPRi Kinase Phosphatase Drug Targets Kit contains 2 sub-pools of top 5 gRNAs per gene as well as a separate sub-pool of 5 supplemental gRNAs per gene for increased sensitivity and includes non-targeting controls built in.
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CRISPRi is a potent tool for modulating gene expression. This technology uses dCas9 to act as a synthetic transcription factors by recruiting endogenous transcription repressor complexes to gene promoters and enhancers, resulting in down regulated gene transcription. CRISPRi achieves LOF phenotypes without the limitations of RNAi and CRISPR KO.
