Human hERG Potassium Channel EZCells™
The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia). Synonyms: Kv11.1 Host cell: CHO-K1, division-arrested Gene name: KCNH2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Thr…
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The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia).
Synonyms: Kv11.1
Host cell: CHO-K1, division-arrested
Gene name: KCNH2
Mycoplasma status: Negative (MycoAlert Kit)
Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells
total)
Growth media: Ham’s F12; 10% FBS
Growth characteristics: cells remain viable 1–2 days post-thaw
Storage recommendation: frozen under liquid nitrogen
Functional expression: median K+ current amplitude = 0.45 nA
Recommended assay: manual or automated patch clamp
