Human Recombinant Epigen

Epigen belongs to the family of epidermal growth factor (EGF) ligands. It is expressed in a variety of tissues, including hepatic, testicular, cardiac, pulmonary, and others. Upon binding to EGF receptor expressed on epithelial cells, epigen triggers mitosis (Schneider & Yarden). The strong mitogenic potential can be explained by the low-affinity binding to EGF receptor, which results in downregulation of receptor ubiquitination. Epigen is also expressed in adenocarcinomas, suggesting a role in oncogenesis (Kochupurakkal et al.).