Human Recombinant MIP-3 alpha (CCL20)

Macrophage inflammatory protein-3 alpha (MIP-3 alpha) or CCL20 is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. MIP-3 alpha has been shown to be expressed predominantly in liver, lymph nodes, appendix, peripheral blood lymphocytes, and lungs, and its expression is markedly upregulated by mediators of inflammation such as tumor necrosis factor or lipopolysaccharide (Hromas et al.). MIP-3 alpha signals through the CCR6 receptor, a chemokine receptor that is selectively and highly expressed in human CD34+ cell-derived dendritic cells (Baba et al.; Greaves et al.).