Human Recombinant TNF-receptor 1

Tumor necrosis factor receptor type 1 (TNFR1) is a member of the TNF receptor superfamily and is activated upon binding to TNF-α. TNFR1 activates NF-kB and MAPK pathways, which results in inflammation, apoptosis, and inhibition of tumorigenesis and viral replication. TNFR1 is essential for transducing TNF signals during organogenesis and surviving infections caused by intracellular bacteria (Hehlgans & Pfeffer). Soluble TNFR1 is released into the bloodstream to bind circulating TNF-α and suppress inflammation. Mutations in TNFR1 result in TNFR-associated periodic syndrome that manifests with inflammatory episodes (Turner et al.).