Human Recombinant VEGF R2/KDR Fc

Vascular endothelial growth factor receptor 2/kinase insert domain receptor (VEGF R2/KDR) belongs to the class III subfamily of receptor tyrosine kinases. It is expressed on endothelial cells, endothelial progenitor cells, pancreatic duct cells, retinal progenitor cells, and megakaryocytes (Youssoufian et al.). KDR binds VEGF, which results in activation of Raf/MEK/ERK and PI3K/AKT pathways, which in turn regulate vasculogenesis and angiogenesis (Ferrara et al.; Youssoufian et al.). Studies in mouse models demonstrate that activation of KDR on hepatic endothelial cells stimulates expression of WNT2 and hepatocyte growth factor, which leads to liver regeneration (Rafii et al.). Hematopoietic regeneration and thrombopoiesis after cancer treatment is impaired in the absence of KDR in endothelial cells (Hooper et al.). KDR signaling is also implicated in lung regeneration (Rafii et al.). This protein contains a C-terminus linker (IEGRMD) to an Fc tag (Human IgG1).