InertSep Oligo
InertSep Oligo is a solid-phase extraction (SPE) product for oligonucleotide purification in LC/MS workflows. It delivers high recovery, low variability, and full LC/MS compatibility. Formats include 96-well plates—Micro Elution (2 mg/400 µL) and 2 mL square-well (25 mg)—and straight barrel cartridges in multiple sizes for manual or automated high-throughput sample prep.
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InertSep Oligo is a WAX-based solid-phase extraction (SPE) product engineered for oligonucleotide sample preparation in LC/MS workflows. It delivers high recovery, low variability, and complete LC/MS compatibility—key to reliable quantitation when distinguishing parent oligonucleotides from metabolites.
Oligonucleotide therapeutics are gaining momentum for their high target specificity and low toxicity. While ligand-binding assays remain widely used, LC/MS methods are increasingly preferred in parts of development due to superior selectivity. In these workflows, robust, reproducible sample prep is essential.
InertSep Oligo supports both manual and automated high-throughput processing with multiple format options:
96-Well Plate Format
- Micro Elution: 2 mg / 400 µL
- 2 mL square-well: 25 mg / 2 mL
Straight Barrel Cartridge Format
- 10 mg / 1 mL
- 30 mg / 3 mL
- 60 mg / 3 mL
- 150 mg / 6 mL
All formats use the same WAX sorbent, ensuring consistent performance across scales and platforms
