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ISCK03

SCF/c-KIT pathway inhibitor; Inhibits c-KIT

STEMCELL Technologies Inc.

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ISCK03 (inhibitor of SCF/c-KIT) is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits KIT activity. ISCK03 inhibits SCF-induced c-KIT phosphorylation and downstream ERK phosphorylation at a concentration of 1 - 5 µM in 501mel melanoma cells (Na et al.).

CANCER RESEARCH

  • Causes significant decrease in blood vessel density on human lung adenocarcinoma (A549) cells irradiated with X-rays (6 Gy; Kamlah et al.).
  • Reduces cell viability and ERK1/2 phosphorylation in acute myeloid leukemia (AML)-derived cell lines (Kon et al.).

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