KREX i-Ome Discovery Services
KREX™ i-Ome™ Discovery Services enable highly multiplexed autoantibody profiling for rapid, reproducible discovery across diverse diseases. The platform measures antibody binding to 1,800+ full-length, correctly folded human proteins – preserving conformational epitopes for highly specific and biologically relevant autoantibody detection. It provides valuable insight into immune responses in health, disease and treatment.
KREX arrays for antibody profiling
Antibody binding on KREX arrays
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KREX i-Ome Discovery Services provide researchers with access to a high-plex platform for autoantibody profiling across oncology, immunology, infectious disease and more. Powered by proprietary KREX technology, this protein array ensures that only properly folded, full-length proteins are displayed – preserving native conformational epitopes that are essential for accurate and biologically relevant autoantibody detection.
Unlike arrays that display denatured or truncated proteins, KREX enables reproducible, high-resolution insights into immune responses and disease mechanisms. It also profiles an often-overlooked yet critical subset of the immunoproteome, representing approximately 20% of the human plasma proteome: antibodies.
Key Features & Benefits
- High specificity: Only correctly folded proteins are available for antibody binding
- Exceptional reproducibility: Low false discovery rate (FDR) of <1%
- Dual isotype analysis: Simultaneous insights into two antibody isotypes (i.e., IgG, IgM, IgA)
- Broad protein coverage: Spans diverse protein classes and disease categories
- Scalable and high-throughput: Supports both discovery and large-cohort studies without compromising quality
- Data-rich outputs: Includes comprehensive, easy-to-interpret reports
Relevant Applications
- Autoantibody and autoantigen biomarker discovery
- Disease stratification and subgroup analysis
- Immune response profiling
- Drug and vaccine development
Ready to discover novel biomarkers?
Speak with an expert to learn how KREX i-Ome Discovery Services can accelerate your autoantibody research. Contact us today to get started.
