KRIBIOLISA™ Rituximab ELISA
The Rituximab ELISA kit is intended for the quantitative determination of Rituximab in serum, plasma and cell culture samples. Validated against International NIBSC standards by WHO.
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Assay Background:
Rituximab is a genetically engineered chimeric murine / human monoclonal IgG1 kappa antibody directed against the CD20 antigen, which is primarily found on the surface of B cells. Rituximab is used in the treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders. Unwanted immunogenicity from rituximab can manifest itself through anti-drug antibody (ADA) responses. ADA responses can lead to allergic reactions, reduction or neutralization of the activity of the drug and in some cases cross-reactive immune responses, which could lead to serious adverse events.
- Calibrator Range: 0 ng/ml - 640 ng/ml
- Sensitivity: 9.4 ng/ml
- Sample Type: Serum and Plasma
- Reactivity: Human
- Shipping Condition: 2 - 8 Deg C
- Detection Method: Colorimetric
- Usage: For In-Vitro Diagnostic Use (CE IVD); RUO available on request
- Research Area: Immunotherapy Therapeutic Drug Monitoring Cancer
About the Rituximab ELISA kit:
- Uses anti-idiotypic antibodies sourced from our vendor partner in the US, which ensures higher specificity, and low cross reactivity
- Recovery rates are 80 - 120%
- Validated as per US FDA guidelines for Bioassays
- Optimized for matrix effects to ensure higher sensitivity
- Uses the innovator drug as calibrator, and is optimized for biosimilars studies
