Products & ReviewLife Sciences
Ku-0063794
mTOR pathway inhibitor; Inhibits mTORC1 and mTORC2 complexes
Ku-0063794
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Ku-0063794 is a cell-permeable, selective inhibitor of the serine-threonine kinase mammalian target of rapamycin (mTOR), inhibiting both the mTORC1 and mTORC2 complexes (IC₅₀ = 10 nM). It shows good specificity (> 1000-fold) against 76 other protein kinases or 7 lipid kinases, including PI3 kinases (García-Martínez et al.).
MAINTENANCE
- Extends the lifespan of Toll-like receptor (TLR)-activated dendritic cells by preserving mitochondrial oxidative phosphorylation (Amiel et al.).
CANCER RESEARCH
- Inhibits cell growth by inducing G1-cell cycle arrest in mouse embryonic fibroblasts and human non-small cell lung carcinoma cell lines (García-Martínez et al.; Fei et al.).
- Inhibits tumor growth in a xenograft model of renal cell carcinoma (Zhang et al.).
- Reduces keloid (fibroproliferative dermal lesion) volume in an ex vivo keloid organ culture model, and inhibits keloid cell spreading, proliferation, migration, and invasive properties in vitro (Syed et al.).
