LDN193189

LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC50 = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.). It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.). This product is supplied as the dihydrochloride salt of the molecule and it is the most soluble version of LDN193189.

DIFFERENTIATION

• Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.).
• Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.).
• Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.).
• Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.).

CANCER RESEARCH

• li>Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.).
• Prevents ovarian cancer cell proliferation (Tsai et al.).