Leptin Knockout Rat — KiloRat™
Leptin is essential for energy intake and expenditure. It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood…
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Leptin is essential for energy intake and expenditure.
It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood pressure.
Leptin Knockout Rat — KiloRat™ Characteristics:
- This model possesses a 151 bp deletion within Exon 1 on chromosome 4
- Homozygous knockout rats display loss of Leptin protein via Western blot
- Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates
- Homozygous knockout rats demonstrate insulin resistance
- Homozygous knockout rats show greatly elevated serum cholesterol levels
- Background Strain: Sprague-Dawley
Research Applications:
- Obesity
- Type II diabetes
- Atherogenesis
- Atherosclerosis
- Hypertension
- Insulin resistance
- Lipoprotein/Cholesterol transportation
- Metabolism (Triglyceride/Cholesterol)
