LightSwitch™ 3´UTR Reporter GoClone™ Collection
For use with The LightSwitch™ Luciferase Assay System to measure the impact of a 3´UTR on post-transcriptional regulation
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LightSwitch 3'UTR Reporter constructs are ideal for performing miRNA target validation, as well as assessing the functional impact of miRNA-3'UTR interactions.
In combination with our miRNA Mimics and Inhibitors, which are co-transfected with the 3'UTR Reporter constructs, you have everything needed to validate miRNA targets, measure RNA stability, translation efficiency and the functional impact of miRNAs on a gene-by-gene basis. We also offer over 900 optimized LightSwitch Synthetic miRNA Target Reporter constructs, which can provide increased response relative to the endogenous sequences cloned into the LightSwitch 3'UTR Reporter constructs.
The 3´UTR activity can be measured to quantitively characterize:
- The impact of the UTR on post-transcriptional gene regulation
- The impact of a miRNA or siRNA on the regulation of transcript stability or translation efficiency
- The targets of a miRNA or siRNA
- The effect of sequence variants on UTR function
- The impact of miRNA inhibitors or stimuli
