Lung Slice Culture
Bio S&T has successfully established an ex vivo rat lung slice culture (LSC) system which bridges the advantages of in vivo model with the ease of in vitro techniques. Extensive experiments have shown that the system is highly consistent and stable on induction of collagen formation. Early alveolar fibrotic features can be induced within a much shorter time (days) compared to the animal model. Increasing collagen content in th…
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Bio S&T has successfully established an ex vivo rat lung slice culture (LSC) system which bridges the advantages of in vivo model with the ease of in vitro techniques. Extensive experiments have shown that the system is highly consistent and stable on induction of collagen formation. Early alveolar fibrotic features can be induced within a much shorter time (days) compared to the animal model. Increasing collagen content in the lung slices can be detected by quantitative analysis of hydroxyproline. Expression of fibrosis-related genes expression can also be observed via PCR. The LSC platform is powerful in that it allows for compound screening with the relevant and appropriate controls in a sequential manner, with the concomitant opportunity to conduct tissue morphology analyses. All these attributes make LSC the best choice available for effective compound screening in relation to control of pulmonary fibrosis.
